10th Annual Biomechanics Research Symposium

Friday, May 3, 2013

Clayton Hall | Conference Center
University of Delaware

Carolee Winstein

Learning and Memory Processes: Mechanisms and Application to Task-Oriented Practice for Stroke Recovery

Carolee J. Winstein, PhD, PT, FAPTA

Professor in the Department of Biokinesiology & Physical Therapy and Director of the Motor Behavior and Neurorehabilitation Laboratory at the University of Southern California in Los Angeles, California

In a 2006 paper, John Krakauer made the following observation: “There have been surprisingly few studies of motor learning after stroke and almost none looking at deficits in motor memory formation despite the likely relevance of these processes to rehabilitation” (Krakauer, 2006, p.85). This lecture describes three projects from my laboratory motivated by Krakauer’s 2006 observation.  First, we describe the mechanisms of the contextual interference effect in individuals post stroke using a computational model of motor memory. We then describe the neural substrates of motor memory consolidation in non-disabled adults using an rTMS paradigm. We follow this with an fMRI study demonstrating how action observation modulates the motor system after stroke. Finally, we conclude with a description of the principle-based application, the Accelerated Skill Acquisition Program (ASAP) delivered early between 1 and 3 months post stroke in the out-patient setting. This intervention is currently under investigation for its effectiveness in the phase III ICARE multi-site RCT.
Brief Biography
Dr. Winstein runs an interdisciplinary research program focused on understanding control, rehabilitation and recovery of goal-directed movements that emerge from a dynamic brain-behavior system in brain-damaged conditions. With NIH funding, she and her team are leading a multi-site phase III randomized controlled trial—ICARE (Interdisciplinary Comprehensive Arm Recovery Evaluation) stroke initiative--to improve outpatient therapy for arm paresis after stroke. With funding from the Foundation for Physical Therapy, she led the first Physical Therapy Clinical Research Network, PTClinResNet that supported clinical research on the effectiveness of task-specific/muscle-specific training to enhance muscle performance and functional activities across four disability groups including adult spinal cord injury, children with cerebral palsy, adult stroke, and low back pain. In 2008, with NIDRR/DoE funding, she and her colleagues at USC and Rancho Los Amigos National Rehabilitation Hospital established a Rehabilitation Engineering Research Center (RERC) to study the challenges of growing older with and into disabilities and the positive effects that new technologies can have on independence, health and quality of life. Recently with funding from NICHD and in collaboration with colleagues at USC, Winstein launched a new development-of-concept trial, Optimizing Dosage of Rehabilitation after Stroke (DOSE) to ultimately determine prospectively the dose of therapy that maximizes the efficacy of treatment—determine the smallest effective dose for individual patients.


  • Poster and podium presentations will be given by students with awards for the best presentations
  • Check out ongoing biomedical research projects
  • Social interaction and networking among faculty, students, clinical collaborators and industry professionals
  • Morning snack and lunch provided for all who register

Abstract Submission and Deadline Information

  • Abstract Submission Form- CLOSED
  • Abstract deadline is Tuesday, April 2, 2013.
  • Poster size requirement: no larger than 3' x 4' vertical or horizontal


8:30 Breakfast & Poster set-up
9:00 Welcome & Introductory Remarks
Dr. Darcy Reisman, Assistant Professor in the Department of Physical Therapy
9:15 Keynote Lecture:
Dr. Carolee Winstein
Learning and Memory Processes: Mechanisms and Application to Task-Oriented Practice for Stroke Recovery
Professor in the Department of Biokinesiology & Physical Therapy at the University of Southern California
10:15 Break
10:30 Podium Session 1
12:00 Lunch
1:00 Poster Session 1 (odds)
2:00 Poster Session 2 (evens)
3:00 Podium Session 2
4:30 Awards Session
5:00-7:00 Cocktail Reception: Newark Courtyard Marriott Outside Patio
Live Music by Tyler Richardson & Bill Handy

RVSP by Friday, April 19, 2013

***PDF of Program Events***

More Information:
2012 CBER Research Symposium program
UDaily article on 2012 CBER Research Symposium

Contact Elaine Nelson for more information